Endocrine Abstracts

Objectives: Primary aldosteronism (PA) is considered to be the most common cause of secondary hypertension. Therefore, a relevance of early diagnosis of PA is obvious.Methods: We evaluated 98 patients with hypertension in age 47.8±1.4 years. We measured serum potassium by indirect porentiometry, serum aldosterone and plasma rennin activity (PRA) by RIA, serum corticosterone (B), 18-hydroxycorticosterone (18-OH-B), 11-deoxycorticosterone (DOC), 11-de...

Introduction: Prolonged QTc interval is a known risk factor for developing ventricular tachyarrhythmias. QTc prolongation is often reported in patients with pheochromocytoma, however the literature data on this issue are rather heterogeneous. Here we report the results of QTc measurement in patients with pheochromocytoma and paraganglioma (PPGL) in comparison to hormonally inactive benign adrenal tumors.Methods: The test group included 204 patients with ...

In 2000 female, 28 y.o., admitted endocrinologist with headache, high blood pressure, dark skin and muscle weakness. Lab data showed high levels of ACTH and cortisol, low potassium level. According to MRI scans, pituitary gland seemed normal. On CT in right adrenal was found 32 mm mass with the native density of 20 HU. Diagnosed ACTH-dependent Cushing syndrome (CS). As Mitotane was not available in Russia at that time, she received ketokonazole due to progression of CS but it ...

Background: The medullary thyroid carcinomas comprise 5-7% of all thyroid carcinomas. At the same time, they are responsible for up to 13% of all deaths of thyroid cancer.Incidence of sporadic medullary thyroid cancer in population 5-6 time higher in women, probably partially because women are likely to have thyroid nodules and undergo medical examination.Objective: The aim of the study is to determine how gender affects prognosis in patient...

Background Undetected multiglandular disease (MGD) is a leading cause of persistent primary hyperparathyroidism after surgical treatment. There is still a number of clinically significant parathyroid adenomas that remain unseen preoperatively.Materials and methods A retrospective cohort study was conducted in order to reveal factors associated with risk of MGD. 810 cases of pHPT patients who had received primary surgical treatment at SPBU Hospital in 201...

Background: Bethesda IV is the most common indication for thyroid surgery. As histological verification is the only 100% certain method of confirming malignancy, surgery remains the gold standard for FN treatment. Most cases of FN malignancy are variants of papillary thyroid cancer that require active surveillance alone in nodules sized less than 2 cm.Materials: A continuous cohort of 4399 patients who underwent surgery at SPbU_Hospital in the years 2020...